Coming from these starting points:

Traveling west bound (from the east end headed toward downtown) on I71 or I64, or

Traveling east bound (from the west end headed toward downtown) on I64,

take the exit for I65 south. Take the St. Catherine Street exit, # 135.  Turn left onto Sixth Street. Follow Sixth Street to - Gallery House at 1386 Sixth Street. There's a sign in the front yard.

Coming from these starting points:

Traveling west bound (from the east end/St. Matthews area toward the airport) on I264/Watterson Expressway, or

Traveling east bound (from the general area of Dixie Highway toward the airport) on I264/Watterson Expressway,

take the exit for I65 north.  Take the St. Catherine Street exit, # 135.  Turn left onto Sixth Street. Follow Sixth Street to - Gallery House at 1386 Sixth Street. There's a sign in the front yard.

Coming from these starting points:

Traveling south on I65 from Indiana,

Traveling north on I65 in Kentucky, 

take the St. Catherine Street exit, # 135.  Turn left onto Sixth Street. Follow Sixth Street to - Gallery House at 1386 Sixth Street. There's a sign in the front yard.